Acetyl Tetrapeptide-5
SkincareAlso known as: Eyeseryl, β-Ala-His-Ser-His, Carelab EYS
Limited EvidenceWhat is Acetyl Tetrapeptide-5?
A synthetic tetrapeptide developed specifically for the periorbital area, targeting under-eye puffiness and dark circles through reduction of capillary permeability and improvement of lymphatic drainage. Marketed under the trademark Eyeseryl by Lipotec (Lubrizol Advanced Materials).
How it works
Reduces edema formation in the under-eye area by strengthening blood vessel walls and reducing excessive capillary permeability — reducing plasma leakage that contributes to puffiness. Also inhibits glycation (protein cross-linking from glucose), which contributes to skin stiffening and loss of elasticity around the eye area. Some data suggests it supports lymphatic drainage by improving capillary vessel integrity.
What marketers claim
- ▸eliminates dark circles permanently
- ▸completely removes bags under the eyes
- ▸works as quickly as topical fillers
What evidence supports
- ✓manufacturer study (Lipotec): 20% reduction in under-eye edema measured by 3D imaging after 28 days at 4% concentration
- ✓in vitro data shows reduction in capillary permeability markers in endothelial cell cultures
- ✓anti-glycation activity documented in cell culture studies
Research evidence
Key studies on Acetyl Tetrapeptide-5, summarized in plain language. This is not an exhaustive list — it highlights the most relevant findings.
Eyeseryl (Acetyl Tetrapeptide-5) for periorbital edema reduction
Finding: 20 volunteers applied 4% Acetyl Tetrapeptide-5 eye cream twice daily for 28 days; 3D volumetric imaging showed ~20% reduction in periorbital volume vs baseline.
Limitation: Manufacturer-sponsored, no placebo control arm described, very small sample (20 subjects).
Best for
What to expect
Realistic timeline based on available research. Individual results vary.
Week 2–4
Under-eye puffiness may show mild improvement with consistent twice-daily application, particularly in the morning when edema is highest.
Month 2–3
Anti-glycation benefits and structural capillary integrity improvements require sustained use.
Safety notes & concerns
Full safety guide →- ⚠evidence limited to manufacturer-sponsored studies — no independent clinical trials
- ⚠under-eye puffiness has multiple causes (genetics, fluid retention, allergies, sleep) — one peptide cannot address all of them
- ⚠effective concentration in commercial products rarely disclosed or likely far below the studied 4%
- ⚠dark circles from pigmentation or vascular visibility are different mechanisms from edema — this peptide specifically targets edema and permeability
Pairs well with
Use caution with
Frequently asked questions
Can Acetyl Tetrapeptide-5 remove dark circles?
It depends on the cause. Dark circles from puffiness (bags casting a shadow) may improve as edema reduces. Dark circles from visible blood vessels under thin skin may improve marginally via capillary permeability reduction. Dark circles from pigmentation (melanin deposits) are a different mechanism entirely and are not addressed by this peptide. Most people have more than one contributing factor.
Related skincare peptides
fine lines, aging skin, anti-aging prevention
expression lines, forehead wrinkles, crow's feet
mature skin, anti-aging prevention, sensitive skin that cannot tolerate retinol
expression lines, forehead wrinkles, those seeking a step up from Argireline
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Last updated: 2026-06-10
Medical Disclaimer
The information on this site is for educational and informational purposes only. It is not intended as medical advice and should not be used to diagnose, treat, or prevent any condition. Always consult with a qualified healthcare professional before starting any new supplement, peptide, or treatment protocol.